The Georgia Tech Hotel is at 800 Spring Street (a north-south street), and the Conference Center attached to the hotel is right around the corner at 84 Fifth Street NW. They are almost equidistant from the Georgia Tech campus to the west and the MARTA light rail line to the east which comes up from Hartsfield-Jackson Atlanta International Airport. For various transportation options from the airport to the hotel, see the hotel website.
There is a special shared-ride shuttle service called Atlanta Link (404-524-3400) between the airport and Georgia Tech Hotel that leaves every half hour. Atlanta Link is the shuttle service that the hotel recommends to its guests. Rates are $18 one way or $32 round trip.
If you take the MARTA (Metropolitan Atlanta Rapid Transit Authority) city train from the airport, get off either at the North Ave. station or Midtown station. The hotel is an easy walk from either station. If you get off at North Ave. station, turn right onto West Peachtree Street and walk north to 5th Street, then turn left onto 5th Street and walk west one block to Spring St. where the hotel is. If you get off at Midtown station, you can take Georgia Tech's complimentary shuttle, the Tech Trolley, to the hotel. It runs at four minute intervals on weekdays and 25-30 minute intervals on Saturday and Sunday. (Other ground transportation options.)
Other shared ride shuttles that run to various hotels in the midtown area of Atlanta (Fulton County) are listed in the Fulton County section of this airport website.
If you are driving a rental car from the airport, go north on Interstate75/85 and exit at 10th/14th Street exit (#250). Turn right onto 10th Street, go one block to Spring Street, turn right again and drive south approx. 0.4 mile to the hotel which will be on the right.